Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease. Publication types Review MeSH terms
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Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease. I. INTRODUCTION
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GLUT-4 protein concentration increased (P < 0.001, 2,629 +/- 331 to 4,140 +/- 391 absorbance units/100 micrograms protein) with exercise training by 1.8-fold. ISI increased by twofold (P < 0.05, 2.1 +/- 0.5 to 3.4 +/- 0.7 SI x 10 (5) min/pM) with training.
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To directly test whether transcription of the GLUT-4 gene is activated in response to exercise training, nuclei were isolated from red hindlimb skeletal muscle of rats after 1 wk of exercise training (8% grade, 32 m/min, 40 min, twice/day). Rats were killed either 30 min, 3 h, or 24 h after the last training session. GLUT-4 transcription, determined by nuclear run-on analysis, was …
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Results indicated that high-intensity exercise increased insulin-stimulated glucose uptake and skeletal muscle Akt phosphorylation (but not glycogen synthase activity), differing from previous findings involving moderate-intensity exercise (discussed above and below).
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A fundamental adaptation to exercise training is the increase in glucose transporter 4 (GLUT4) protein in skeletal muscle [6]. GLUT4 is one of 13 facilitative glucose transport proteins.
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Exercise training improves peripheral insulin sensitivity and leads to molecular adap- tations in the skeletal muscle. We investigated changes in the expression of key mus- cle proteins in the glucose metabolic pathway following active commuting by bike or leisure- time exercise at two different intensities. In addition, potential associations
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Glycogen synthesis in skeletal muscle correlates with glucose uptake into the muscle cell, and GLUT4 is the major glucose transporter protein expressed in skeletal muscle. One week of exercise training resulted in a significant (50%) increase in GLUT4 protein level FEBS Journal 280 (2013) 916–926 ª 2012 The Authors Journal compilation ª
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Exercise and insulin utilize different signaling pathways, both of which lead to the activation of glucose transport, which perhaps explains why humans with insulin resistance can increase muscle glucose transport in response to an acute bout of exercise. Exercise training in humans results in numerous beneficial adaptations in skeletal muscles, including an increase in …
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Muscle GLUT-4 increased (P < 0.05) by an average of 2.8 +/- 0.5-fold with 7 days of training. GLUT-4 content in skeletal muscle thus increases substantially with short-term exercise training. Previous Back to Top Next
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Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease. Previous Back to …
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Does GLUT4 increase with exercise? Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease.
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Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin …
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As a result, the suggestion has been made that because the half-life of the GLUT4 protein is longer than that of Glut4 mRNA, the gradual increase in GLUT4 protein observed with exercise training is the product of repeated, though transient, increases in Glut4 transcription, which allows for skeletal muscle remodeling (and increased GLUT4 expression) over time .
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Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4
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We investigated the effects of exercise training on adipose tissue and skeletal muscle GLUT4 expression in patients with type 2 diabetes (T2D). Muscle and adipose tissue samples were obtained befor
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The present study demonstrated that GLUT-4 in VL muscle decreased by ∼16% after 19 days of bed rest, and isometric resistance training during bed rest induced a 30% increase above the value of GLUT-4 before bed rest. skeletal muscle is responsible for at least 80% of insulin-stimulated glucose uptake.
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Indeed, with repeated exercise bouts (training), although all studies demonstrate increased skeletal muscle GLUT4 expression, there is variation in individual responses ( 127 ).
EXERCISE-INDUCED GLUT4 skeletal muscle glucose uptake during exercise. This is due GLUT4 intrinsic activity). There has been ongoing debate tered (8, 340).
In human skeletal muscle, a single exercise bout results in increased skeletal muscle GLUT4 mRNA immediately after exercise ( 173, 174, 201 ), and it remains elevated for several hours after exercise ( 173, 174 ), but appears to return to preexercise levels within 24 h ( 173 ).
Eccentric exercise decreases glucose transporter GLUT4 protein in human skeletal muscle. J Physiol 482: 705–712, 1995. 14. Asp S, Kristiansen S, Richter EA. Eccentric muscle damage transiently decreases rat skeletal muscle GLUT-4 protein.