How Does Exercise Training Increase Skeletal Muscle Glut4

Listing Results How does exercise training increase skeletal muscle glut4


Preview

Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease. Publication types Review MeSH terms

Author: Erik A. Richter, Mark Hargreaves
Publish Year: 2013

See Also: Free Online Courses  Show details


Preview

Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease. I. INTRODUCTION

Author: Erik A. Richter, Mark Hargreaves
Publish Year: 2013

See Also: Free Online Courses  Show details


Preview

GLUT-4 protein concentration increased (P < 0.001, 2,629 +/- 331 to 4,140 +/- 391 absorbance units/100 micrograms protein) with exercise training by 1.8-fold. ISI increased by twofold (P < 0.05, 2.1 +/- 0.5 to 3.4 +/- 0.7 SI x 10 (5) min/pM) with training.

Author: J. A. Houmard, M. H. Shinebarger, P. L. Dolan, N. Leggett-Frazier, R. K. Bruner, M. R. McCammon, R.
Publish Year: 1993

See Also: Training Courses  Show details


Preview

To directly test whether transcription of the GLUT-4 gene is activated in response to exercise training, nuclei were isolated from red hindlimb skeletal muscle of rats after 1 wk of exercise training (8% grade, 32 m/min, 40 min, twice/day). Rats were killed either 30 min, 3 h, or 24 h after the last training session. GLUT-4 transcription, determined by nuclear run-on analysis, was …

Author: P. D. Neufer, G. L. Dohm
Publish Year: 1993

See Also: Free Online Courses  Show details


Preview

Results indicated that high-intensity exercise increased insulin-stimulated glucose uptake and skeletal muscle Akt phosphorylation (but not glycogen synthase activity), differing from previous findings involving moderate-intensity exercise (discussed above and below).

Author: Leslie A. Consitt, Courtney Dudley, Gunjan Saxena
Publish Year: 2019

See Also: Training Courses  Show details


Preview

A fundamental adaptation to exercise training is the increase in glucose transporter 4 (GLUT4) protein in skeletal muscle [6]. GLUT4 is one of 13 facilitative glucose transport proteins.

See Also: Free Online Courses  Show details


Preview

Exercise training improves peripheral insulin sensitivity and leads to molecular adap- tations in the skeletal muscle. We investigated changes in the expression of key mus- cle proteins in the glucose metabolic pathway following active commuting by bike or leisure- time exercise at two different intensities. In addition, potential associations

See Also: Training Courses  Show details


Preview

Glycogen synthesis in skeletal muscle correlates with glucose uptake into the muscle cell, and GLUT4 is the major glucose transporter protein expressed in skeletal muscle. One week of exercise training resulted in a significant (50%) increase in GLUT4 protein level FEBS Journal 280 (2013) 916–926 ª 2012 The Authors Journal compilation ª

See Also: Training Courses, It Courses  Show details


Preview

Exercise and insulin utilize different signaling pathways, both of which lead to the activation of glucose transport, which perhaps explains why humans with insulin resistance can increase muscle glucose transport in response to an acute bout of exercise. Exercise training in humans results in numerous beneficial adaptations in skeletal muscles, including an increase in …

See Also: It Courses  Show details


Preview

Muscle GLUT-4 increased (P < 0.05) by an average of 2.8 +/- 0.5-fold with 7 days of training. GLUT-4 content in skeletal muscle thus increases substantially with short-term exercise training. Previous Back to Top Next

See Also: Free Online Courses  Show details


Preview

Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease. Previous Back to …

See Also: Free Online Courses  Show details


Preview

Does GLUT4 increase with exercise? Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease.

See Also: It Courses  Show details


Preview

Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin …

See Also: Free Online Courses  Show details


Preview

As a result, the suggestion has been made that because the half-life of the GLUT4 protein is longer than that of Glut4 mRNA, the gradual increase in GLUT4 protein observed with exercise training is the product of repeated, though transient, increases in Glut4 transcription, which allows for skeletal muscle remodeling (and increased GLUT4 expression) over time .

See Also: Free Online Courses  Show details


Preview

Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4

See Also: Free Online Courses  Show details


Preview

We investigated the effects of exercise training on adipose tissue and skeletal muscle GLUT4 expression in patients with type 2 diabetes (T2D). Muscle and adipose tissue samples were obtained befor

See Also: Training Courses  Show details


Preview

The present study demonstrated that GLUT-4 in VL muscle decreased by ∼16% after 19 days of bed rest, and isometric resistance training during bed rest induced a 30% increase above the value of GLUT-4 before bed rest. skeletal muscle is responsible for at least 80% of insulin-stimulated glucose uptake.

See Also: Training Courses  Show details

Please leave your comments here:

New Online Courses

Frequently Asked Questions

Does exercise increase GLUT4 expression in skeletal muscles??

Indeed, with repeated exercise bouts (training), although all studies demonstrate increased skeletal muscle GLUT4 expression, there is variation in individual responses ( 127 ).

Does exercise increase glucose uptake in skeletal muscle during exercise??

EXERCISE-INDUCED GLUT4 skeletal muscle glucose uptake during exercise. This is due GLUT4 intrinsic activity). There has been ongoing debate tered (8, 340).

How long does it take for GLUT4 levels to increase??

In human skeletal muscle, a single exercise bout results in increased skeletal muscle GLUT4 mRNA immediately after exercise ( 173, 174, 201 ), and it remains elevated for several hours after exercise ( 173, 174 ), but appears to return to preexercise levels within 24 h ( 173 ).

What is the effect of eccentric exercise on glucose transporter GLUT4 protein??

Eccentric exercise decreases glucose transporter GLUT4 protein in human skeletal muscle. J Physiol 482: 705–712, 1995. 14. Asp S, Kristiansen S, Richter EA. Eccentric muscle damage transiently decreases rat skeletal muscle GLUT-4 protein.

Popular Search